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- Weekly Signal: 10
Weekly Signal: 10
Paradromics hits a milestone with human neural recording, AI transforms diagnostics, and new pathways emerge for preventing Alzheimer’s and detecting dementia early.
Ricardo Albornoz
June 07, 2025
Table of Contents
🧠 Weekly Signal
Neurotechnology News | May 31 – June 6, 2025
Let's cut through the noise this week!
🧩 Paradromics Launches Clinical Era with First Human BCI Recording
Published: June 2, 2025
Source: [Paradromics Official Release]
In partnership with the University of Michigan, Paradromics successfully completed its first-in-human recording using the Connexus® BCI. Implanted temporarily during an epilepsy surgery, the device recorded electrical brain activity at the individual neuron level—then was removed in under 20 minutes without complication.
The Connexus BCI is designed to restore speech and movement for people with severe neurological injuries or disorders such as ALS and stroke. This milestone transitions Paradromics into its clinical-stage roadmap, with additional surgeries and trials planned over the next several months.
💡 Why it matters:
Paradromics positions itself as a direct competitor to Neuralink but with a clearer path toward FDA trials. This procedure validates real-world feasibility for scalable, high-resolution neural recording platforms in human patients.
👁️ AI-Powered Smartphone Tool Diagnoses Neuro-Ocular Disorders
Published: June 3, 2025
Source: [Science Advances, peer-reviewed]
Researchers developed a smartphone-based video capture system powered by deep learning to diagnose nystagmus—a neuro-ocular disorder that can indicate vestibular dysfunction, strokes, or neurological disease. The tool achieved detection performance comparable to lab-grade videonystagmography systems.
The system uses regular video and cloud-based analysis to track eye movement velocity, direction, and pattern, identifying abnormal rhythms with clinical-level accuracy.
💡 Why it matters:
This technology can dramatically increase access to neurodiagnostic tools, especially in underserved areas, emergency rooms, or even at-home telehealth setups.
🧬 Epileptic Seizures May Predict Dementia by a Decade
Published: June 2, 2025
Source: [JAMA Neurology]
A groundbreaking study revealed a strong association between epilepsy and frontotemporal dementia (FTD). Patients with FTD had a significantly higher history of seizures up to 10 years before diagnosis. Researchers propose using antiseizure medication as a potential intervention path or risk signal for earlier detection of cognitive decline.
The study used a combination of clinical data and population tracking to uncover hidden diagnostic timelines and therapeutic gaps.
💡 Why it matters:
This insight may lead to seizure monitoring as an early warning system for neurodegeneration and influence clinical practices surrounding EEG screening and preventative interventions.
🧠 Immune Pathway STING Identified as Alzheimer’s Accelerator
Published: 23 May 2025
Source: [Cell Reports]
New research highlights the STING immune signaling pathway as a driver of Alzheimer’s-related inflammation and neurodegeneration. In mouse models, suppressing STING activity led to measurable improvements in memory and reduction in brain inflammation.
The findings suggest STING inhibitors could form the basis of novel therapeutic strategies to halt or reverse cognitive decline.
💡 Why it matters:
The study links innate immune dysfunction to neurodegenerative disease progression, offering new hope for targeted drug development beyond amyloid plaques.
⚡ Signal Summary
Signal | Key Insight | Why It Matters |
|---|---|---|
Paradromics BCI | First human neural recording with Connexus BCI | Validates commercial BCI readiness for clinical use |
AI Eye Diagnosis | Smartphone tool detects nystagmus with deep learning | Makes neuro-ocular diagnostics more accessible |
Seizure-Dementia Link | Epilepsy precedes FTD by up to 10 years | Enables earlier dementia detection & treatment paths |
STING in Alzheimer’s | Overactive immune pathway accelerates neurodegeneration | Introduces immune-modulating therapies for AD |
⚡ Innovator Spotlight
In our Innovator Spotlight, we celebrate members of The NeuroCircuit community who are pushing the boundaries of neurotechnology. Each week, we feature a subscriber who has successfully completed our latest Community Challenge. Their innovative approach and dedication exemplify the spirit of collaboration and discovery that drives our community forward.
🛠️ Neurohack Nexus: Live Neurotech Project Repository
The Neurohack Nexus is a continuously updated, open‑source library of neurotechnology projects—complete with code, schematics, step‑by‑step tutorials, and community contributions. Whether you’re a beginner tinkering with your first EEG hack or an advanced builder crafting custom BCI extensions, the Nexus brings together the resources and collaborative spirit you need to learn, build, and innovate.
How useful would you find the Neurohack Nexus? |
📚 Reading Corner (2025)
Curious minds, this one’s for you. Whether you're exploring the mechanics of BCIs, diving into neural engineering, or reflecting on the ethical frontiers of brain science—our curated list of neurotech reads has you covered.
But we’re just getting started—help us expand the list!
👉 What books would you recommend? Share your top picks in our 1-click survey and help shape the future of the NeuroCircuit library.
🎓Academic Resources
Whether you're applying for a master’s in neuroengineering, seeking PhD programs with BCI research, or hunting for summer research internships, our academic resources are your go-to launchpad.
We’re curating a growing list of academic programs, research fellowships, and internship opportunities around the globe. And we’d love your help!
📢 Know a great program, lab, or opportunity?
Share it with the community using our short-survey below 👇️
📅 Upcoming Events (2025)
Stay informed about upcoming neurotech conferences and networking opportunities around the world:
Cognitive Neuroscience Society (CNS) 2025 Annual Meeting
📍 Boston, Massachusetts, USA | March 29–April 1, 2025
NeurotechEU Symposium 2025
📍 Bonn, Germany | May 13, 2025
Neural Interfaces 2025
📍 Arlington, Virginia, USA | June 12–14, 2025
2025 Neurotech Leaders Forum
📍 Location TBA | November 5–6, 2025
Society for Neuroscience 2025 Annual Meeting
📍 San Diego, California, USA | November 15–19, 2025
Maudsley Neurotechnology Conference 2025
📍 King's College London, UK | Dates TBA
Conference on Neural Information Processing Systems (NeurIPS) 2025
📍 San Diego, California, USA | December 2025
🎯 Community Challenge
Ready to take neurotech to the next level? Share your insights, projects, ideas, our upcoming list of NeuroHacks, or your own groundbreaking work—and watch the inspiration ripple across the community!
How to Participate
Create a Post
Show us what you’re working on—DIY projects, research breakthroughs, or even your latest neurotech musings.Use #NeuroCircuitChallenge
This helps your ideas reach fellow enthusiasts and potential collaborators.Tag The NeuroCircuit
We’ll be on the lookout for standout contributions to feature in our upcoming Innovator Spotlight!Mention @HackTheNeuron
Tag us directly in your post so we never miss your entry—and we’ll amplify your work across our entire NeuroCircuit community!
Why Join?
Boost Your Reach: Tap into a niche but fast-growing community for extra visibility.
Build Your Network: Connect with researchers, developers, and curious tinkerers who share your passion.
Shape Neurotech’s Future: Your project or insight could spark the next big breakthrough—or inspire someone else’s.
We can’t wait to see your creativity in action! Fire up X, LinkedIn, Facebook, Instagram, or TikTok, and spread the word. Let’s spark innovation together!
🚀Recruit More Neurohackers
Your referrals are the engine that drives our community forward. Share your unique referral link with friends, colleagues, or fellow neurotech enthusiasts—and watch us grow together!
Spread the Word: Copy your personal referral link and post it on social, forums, or in emails.
Unlock Exclusive Perks: Every friend who subscribes through your link brings you closer to special rewards—insider insights, private Discord access, early project previews, and more.
Be the Catalyst: The more you share, the stronger our network becomes. Help us build the ultimate neurotech hub—one referral at a time!
✍️Help Us Improve
Your input is what will make The NeuroCircuit and Hack The Neuron better. Let us know what you’d like more of—and what we can do differently.
Share Your Ideas: Tell us which topics, features, or formats you’d love to see next.
Spot the Gaps: Let us know if anything’s missing or unclear in our content and community tools.
Shape the Experience: Whether it’s new challenges, tutorials, or platform features, your suggestions guide our roadmap.
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