Weekly Signal: 26 |Gene Therapy, HD-EEG, and Neural Rights

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🧠 Weekly Signal

Gene Therapy, EEG, Governance
Neurotechnology News | Sep 20–Sep 26, 2025

Let's cut through the noise this week!

This week, we saw gene therapy slow Huntington’s disease progression and fresh evidence that high-density electroencephalography can decode vision from single trials. Meanwhile, industry momentum included HD-EEG platform launches and stroke-focused neuromodulation filings, and U.S. lawmakers advanced neural-data protections. Bottom line: neurotech’s clinical, commercial, and governance pillars all moved forward.

🧠 SCIENCE & CLINICAL TRIALS

🟢 Gene therapy slowed Huntington’s disease progression in pivotal study

Published: September 24, 2025
Read more ➡️ Nature / uniQure

In 29 patients, high-dose AMT-130 (AAV-delivered microRNA) reportedly slowed clinical decline by ~75% at 36 months vs. matched natural-history controls, meeting the prespecified endpoint. Safety was acceptable for an intracranial one-time procedure, supporting a planned 2026 U.S. submission.

💡 Big Picture: First credible disease-modifying signal in Huntington’s establishes a clinical path for gene-silencing neurology programs.

🟢 Ultra-high-density EEG decoded image properties from single-trial visual responses

Published: September 25, 2025
Read more ➡️ Scientific Reports paper 

Using a 512-channel ultra-high-density EEG array, researchers decoded visual attributes from single-trial evoked potentials with cross-validated classifiers. Results demonstrate richer information recovery without trial averaging, a key step toward higher-bandwidth noninvasive brain–computer interfaces.

💡 Big Picture: Scaling channel counts and decoding methods is making noninvasive BCI more informative without implants.

💼 INDUSTRY & STARTUPS

🟢 EGI unveiled GES 500, an integrated HD-EEG sensing–stimulation platform

Published: September 24, 2025
Read more ➡️ Magtism / GlobeNewswire 

The Geodesic EEG System 500 integrates high-density EEG hardware, software, and TMS-ready workflows aimed at precision research and translational studies. Positioning emphasizes improved signal quality and streamlined setup for closed-loop applications.

💡 Big Picture: A tighter EEG–stimulation stack could accelerate biomarker discovery and clinical-grade neuromodulation protocols.

🟢 Sonomind raised €3M for patient-specific ultrasound neuromodulation in depression

Published: September 24, 2025
Read more ➡️ Bioworld / Pharmiweb

Funds back first-in-human plans using low-intensity focused ultrasound with custom acoustic lenses to target deep brain regions for treatment-resistant depression. The company also flagged regulatory discussions toward a potential De Novo path.

💡 Big Picture: Tailored ultrasound fields could broaden noninvasive options beyond electromagnetic stimulation.

🏛️ POLICY & ETHICS

🟢 U.S. “MIND Act” would direct FTC to set neural-data governance standards

Published: September 23, 2025
Read more ➡️ The Record / U.S. Senate Commerce press release

The bill instructs the Federal Trade Commission to define safeguards for data from brain–computer interfaces and other neural sensors, covering consent, transparency, and security. Consumer neurotech makers and data brokers would face clearer guardrails if enacted.

💡 Big Picture: Neural-data governance is moving from debate to draft policy, shaping compliance for BCI developers and platforms.

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