Weekly Signal: 31 | FcRn Trials, Neuromodulation Breakthroughs, and Neuro-Rights

In partnership with

Table of Contents

• Weekly Signal

• Complete our community challenge

• Refer a Neurohacker

• Help us Improve

🧠 Weekly Signal

Neurotechnology News | Oct 25–Oct 31, 2025

Let's cut through the noise this week!

This week, we saw head-to-head trial activity in generalized myasthenia gravis and fresh data supporting neonatal Fc receptor (FcRn) strategies. Meanwhile, neuromodulation financing and CRO capacity expanded. Bottom line: regulatory-grade trials and scaled deployment keep tightening the loop from bench to bedside.

🧠 SCIENCE & CLINICAL TRIALS

🟢 J&J launches EPIC head-to-head gMG study (nipocalimab vs efgartigimod)

Published: October 29, 2025
Read more ➡️ NeurologyLive / Press Release

EPIC is a randomized phase 3b study comparing two FcRn blockers in adults with generalized myasthenia gravis (n≈80 FcRn-naïve; switch arm included). Endpoints include change in total IgG and sustained disease control by MG-ADL and QMG at weeks 8–12.

💡 Big Picture: Prospective within-class data could finally guide FcRn selection and switching strategies in routine gMG care.

🟢 Argenx presents VYVGART data including seronegative gMG results

Published: October 29, 2025
Read more ➡️ FiercePharma / Argenx 
Company presentations at AANEM/MGFA highlighted phase 3 ADAPT SERON outcomes in seronegative gMG and long-term/real-world findings across subgroups. Reported measures included MG-ADL improvements and steroid-sparing signals.

💡 Big Picture: Evidence for benefit in seronegative patients could broaden FcRn use and reshape treatment algorithms if labels expand.

💼 INDUSTRY & STARTUPS

🟢 EIB provides €20M venture loan to Precisis for EASEE® expansion

Published: October 30, 2025
Read more ➡️ The European Sting / European Investment Bank 

The European Investment Bank’s venture debt supports manufacturing scale-up, clinical development, and EU market access for Precisis’s minimally invasive epicranial neurostimulation (EASEE®) for focal epilepsy. The financing is backed by InvestEU.

💡 Big Picture: Institutional capital is validating patient-specific neuromodulation and accelerating EU deployment.

🟢 Avance Clinical opens dedicated CNS Center of Excellence

Published: October 28–29, 2025
Read more ➡️ BioSpace / GlobeNewsWire

The CRO’s CNS hub concentrates neuroscience trial design, recruitment, and biomarker expertise across regions to speed first-in-human and later-phase programs. The initiative targets startup and mid-cap sponsors facing site activation and enrollment delays.

💡 Big Picture: Expanded specialist capacity may shorten CNS trial timelines and reduce execution risk for neuro startups.

🏛️ POLICY & ETHICS

🟢 “Minds, Freedoms & Rights” — international conference on neuro-rights and neuro-AI (Amsterdam)

Published: October 30–31, 2025
Read more ➡️ cenetherlands / Program

Legal scholars and ethicists examined mental privacy, evidentiary use of neurodata, and AI-enabled neurotech governance across EU contexts. Sessions focused on rights frameworks and potential constraints on commercial and forensic uses.

💡 Big Picture: Europe is stress-testing governance models that could influence neural data rights and compliance requirements for neurotech firms.

The daily health habit you’ll actually stick with…

This time of year, it’s so easy for your daily routine to be thrown off.

When it starts getting dark before you’re home from work and the Halloween candy is taunting you, it’s important to find something that’s easy to do daily for your body.

That’s where AG1 Next Gen comes in.

With just one quick scoop every morning, you’ll get over 75 ingredients that help support your immune health, gut health, energy and help to close nutrient gaps in your diet.

Click here and you’ll get a free AG1 welcome kit with your first subscription including a:

✔️ FREE Flavor Sample Pack
✔️ FREE Bottle Vitamin D3+K2 Drops
✔️ FREE Canister + Shaker

It’s one of the easiest things you can do for your body every day.

Click here

_{*These statements have not been evaluated by the Food and Drug Administration.}

🎯 Community Challenge

Ready to take neurotech to the next level? Share your insights, projects, ideas, our upcoming list of NeuroHacks, or your own groundbreaking work—and watch the inspiration ripple across the community!

How to Participate

1. Follow HackTheNeuron

   Show us support by following us on X, Instagram and Tik Tok!

2. Create a Post
   Show us what you’re working on—DIY projects, research breakthroughs, or even your latest neurotech musings.

3. Use #Neurotech
   This helps your ideas reach fellow enthusiasts and potential collaborators.

4. Mention @HackTheNeuron
   Tag us directly in your post so we never miss your entry—and we’ll amplify your work across our entire NeuroCircuit community!

Why Join?

• Boost Your Reach: Tap into a niche but fast-growing community for extra visibility.

• Build Your Network: Connect with researchers, developers, and curious tinkerers who share your passion.

• Shape Neurotech’s Future: Your project or insight could spark the next big breakthrough—or inspire someone else’s.

We can’t wait to see your creativity in action! Fire up X, LinkedIn, Facebook, Instagram, or TikTok, and spread the word. Let’s spark innovation together!

🚀Recruit More Neurohackers

Your referrals are the engine that drives our community forward. Share your unique referral link with friends, colleagues, or fellow neurotech enthusiasts—and watch us grow together!

• Spread the Word: Copy your personal referral link and post it on social, forums, or in emails.

• Unlock Exclusive Perks: Every friend who subscribes through your link brings you closer to special rewards—insider insights, private Discord access, early project previews, and more.

• Be the Catalyst: The more you share, the stronger our network becomes. Help us build the ultimate neurotech hub—one referral at a time!

✍️Help Us Improve

Your input is what will make The NeuroCircuit and Hack The Neuron better. Let us know what you’d like more of—and what we can do differently.

• Share Your Ideas: Tell us which topics, features, or formats you’d love to see next.

• Spot the Gaps: Let us know if anything’s missing or unclear in our content and community tools.

• Shape the Experience: Whether it’s new challenges, tutorials, or platform features, your suggestions guide our roadmap.