Weekly Signal: 39 | Clinical Proof, Clearer Signals

Table of Contents

• Weekly Signal

• Complete our community challenge

• Refer a Neurohacker

• Help us Improve

🧠 Weekly Signal

Neurotechnology News | Dec 20–Dec 26, 2025

Final Weekly Signal of 2025

Let's cut through the noise this week!

This week, validated neuromodulation advanced through a pivotal randomized clinical trial, while neuroimaging gained sharper tools for measuring synaptic transmission. No industry or policy developments met our verification criteria. Bottom line: clinical evidence and measurement precision defined the signal.

🧠 SCIENCE & CLINICAL TRIALS

🟢 Implantable vagus nerve stimulation benefits refractory rheumatoid arthritis

Published: Dec 22, 2025
Read more ➡️ reachmd / Nature

A randomized controlled trial evaluated implantable vagus nerve stimulation in patients with treatment-refractory rheumatoid arthritis and reported improved disease activity versus control. This provides controlled clinical evidence that targeted neuromodulation can alter immune signaling in humans.

💡 Big Picture: Electroceuticals continue moving from experimental concepts toward evidence-backed clinical tools.

🟢 New iGluSnFR glutamate sensors improve synaptic imaging

Published: Dec 23, 2025
Read more ➡️ SciTechDaily / Nature

Researchers engineered updated iGluSnFR glutamate indicators with higher sensitivity and customizable kinetics, enabling detection of weaker and faster neurotransmitter signals in vivo. The work improves optical measurement of synaptic transmission across neural circuits

💡 Big Picture: Better molecular sensors strengthen the foundation for circuit-level neuroscience and disease models.

💼 INDUSTRY & STARTUPS

🏛️ POLICY & ETHICS

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